Safer prescribing · MICA
Frequency, interactions and laboratory monitoring.
Sources consulted 16 October 2026 · MICA scientific review to be confirmed
For inflammatory disease: once-weekly administration. Write the day, total dose and formulation; ask the patient to explain the schedule back. Accidental daily dosing can be fatal and requires urgent assessment, even without symptoms. [1]
Monitor blood count, liver and kidney function according to the product protocol and risk. Falling blood counts or rising transaminases matter even before a stopping threshold. Reassess after dose changes or intercurrent illness. [2]
Avoid trimethoprim or co-trimoxazole because of severe marrow toxicity. If unavoidable, obtain specialist advice and enhanced monitoring. Mouth ulcers, fever or bleeding need prompt assessment. [3]
Personal reading prompts; no clinical data is recorded.
FICTIONAL LEARNING SCENARIO
An antibiotic is added to a stable prescription: should interactions be reviewed again?
Yes. Previous stability does not protect against a new interaction, especially co-trimoxazole. [3]
Non-exhaustive adult learning guidance. Check indication, contraindications, product information and local context before an individual decision. Cited recommendations do not establish marketing authorisation in Algeria.