MICA

Histology

Observe the images and explore this collection’s sheets.

← Cytology, histology & pathology

16 sheets

A dense cell population with pink cytoplasm and purple, often eccentric nuclei.

Histology

Plasma-cell proliferation · histology

A plasmacytoma micrograph illustrates plasma-cell morphology; disease extent requires separate assessment.

Cells: Plasma cells
Stain: H&E
Confirmation: Immunophenotype and clonality
Extent: Marrow assessment and imaging

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Original MICA educational diagram

IgG4-related disease: assemble coherent evidence

Four steps connect phenotype, sampling, differential diagnoses and synthesis. No microscopic tissue is artificially reconstructed.

Document: Original educational diagram
Scope: No real examination simulated
Takeaway: An isolated serum IgG4 or immunostain result is insufficient to establish the diagnosis.

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Extracapillary proliferation within Bowman space. Source attribution retained; descriptive MICA reading.

Histology

Glomerulus with an extracapillary crescent

Extracapillary proliferation within Bowman space.

Technique: Histology
Observation: A crescent surrounds part of the tuft.
Limitation: One crescent cannot quantify biopsy-wide involvement.

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Glandular epithelium containing several cells with blue-grey contents.

Histology

Oesophageal intestinal metaplasia · Alcian blue

Recognise blue-stained goblet cells and correlate histology with the endoscopic biopsy site.

Technique: Histology
Stain: Alcian blue
Clue: Goblet cells
Limit: Metaplasia ≠ cancer

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Gastric mucosa with several dilated vascular lumina containing red cells and eosinophilic material.

Histology

Gastric antral vascular ectasia · histology

Dilated mucosal vessels and thrombi support GAVE when the endoscopic context is concordant.

Specimen: Gastric mucosa
Stain: H&E
Clue: Ectasia and thrombi
Presentation: Anaemia or gastrointestinal bleeding

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A glomerular micrograph identified as membranous nephropathy. Source attribution retained; descriptive MICA reading.

Histology

Membranous nephropathy: PAS stain

A glomerular micrograph identified as membranous nephropathy.

Technique: Histology
Observation: The stain highlights capillary walls.
Limitation: A single image cannot identify a specific antigen.

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A micrograph attributed to IgG4-related prostatitis. Source attribution retained; descriptive MICA reading.

Histology

IgG4-related prostatic involvement: histology

A micrograph attributed to IgG4-related prostatitis.

Technique: Histology
Observation: Inflammatory cells involve glandular tissue.
Limitation: An infiltrate alone cannot establish IgG4-related disease.

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Histology

Granuloma · microscopy

A group of epithelioid macrophages, sometimes with giant cells; this pattern does not define one cause.

Cells: Epithelioid macrophages
Giant cells: Possible, not required
Necrosis: Assess presence
Cause: Infectious or non-infectious

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Histology

Perifascicular atrophy · muscle biopsy

Small fibres at fascicle edges: distribution is essential.

Tissue: Skeletal muscle
Distribution: Fascicle periphery
Morphology: Reduced fibre diameter
Direction: Dermatomyositis, in context

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Histology

Amyloid deposits · interpretation and confirmation

Amorphous extracellular material requires specific staining and typing before interpretation as amyloid.

Tissue: Liver
Stain: Congo red
Reading: Birefringence under polarised light
Limitation: The image does not type the protein

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Micrograph of a granuloma attributed to tuberculosis. Source attribution retained; descriptive MICA reading.

Histology

Granuloma: lung biopsy

Micrograph of a granuloma attributed to tuberculosis.

Technique: Histology
Observation: Multinucleated giant cells are visible.
Limitation: Do not assume every field demonstrates caseation.

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Histology

Duodenal villous atrophy · histology

Villous shortening, crypt hyperplasia and intraepithelial lymphocytes described and correlated with investigation.

Villi: Reduced height
Crypts: Possible hyperplasia
Epithelium: Assess lymphocytes
Aetiology: Serology and context

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A micrograph attributed to proliferative lupus nephritis. Source attribution retained; descriptive MICA reading.

Histology

Lupus nephritis: glomerular proliferation

A micrograph attributed to proliferative lupus nephritis.

Technique: Histology
Observation: Increased cellularity accompanies capillary abnormalities.
Limitation: A thumbnail cannot establish activity or chronicity scores.

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Histology

Giant cell arteritis · histology

Arterial inflammation with wall injury and sometimes giant cells; interpret biopsy in context.

Vessel: Artery
Inflammation: Arterial wall
Elastic layer: Assess disruption
Sampling: Possible skip lesions

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The source identifies the micrograph as GPA. Authentic document with original caption context retained.

Histology

Granulomatosis with polyangiitis: micrograph

The source identifies the micrograph as GPA.

Observation: Inflammatory cells are visible in the selected field.
Limitation: Do not invent visible vasculitis in every field.

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Histology

Leukocytoclastic vasculitis · histology

Cutaneous small-vessel involvement with neutrophils, nuclear debris and wall injury.

Vessels: Small dermal vessels
Cells: Neutrophils
Debris: Leukocytoclasia
Wall: Injury and fibrin

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